Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation Discovery of pyridyl urea sulfonamide inhibitors of NaV1.7 Discovery of Potent, Selective, and State-Dependent Na_V1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure–Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors Discovery of Selective Inhibitors of Na_V1.7 Templated on Saxitoxin as Therapeutics for Pain Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent Na_V1.7 inhibitors Discovery of pyrrolo-benzo-1,4-diazines as potent Nav1.7 sodium channel blockers Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na_V1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na_V1.7 Inhibitors A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects