Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies 2-aryl-indolyl maleimides - novel and potent inhibitors of protein kinase C Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer Treatment Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors Synthesis, Protein Kinase Inhibitory Potencies, and in Vitro Antiproliferative Activities of Meridianin Derivatives Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases