Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds Structure–Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity A clinical drug library screen identifies astemizole as an antimalarial agent Antiplasmodial imidazopyridazines: structure–activity relationship studies lead to the identification of analogues with improved solubility and hERG profiles New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amines The Structure−Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277) Identification and Optimization of an Aminoalcohol-Carbazole Series with Antimalarial Properties Structure–activity relationship studies of antiplasmodial aminomethylthiazoles