Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors

Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors Identification of novel ASK1 inhibitors using virtual screening The association between anti-tumor potency and structure-activity of protein-kinases inhibitors based on quinazoline molecular skeleton Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1) Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design Synthesis and Biological Testing of Purine Derivatives as Potential ATP-Competitive Kinase Inhibitors New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies Structure-based design and synthesis of novel pseudosaccharine derivatives as antiproliferative agents and kinase inhibitors