Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ^null Mouse Model of Malaria

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ^null Mouse Model of Malaria Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose–Response Curves against Multidrug Resistant Parasite Strains Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle N-Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines