Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors

Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening Fragment Screening and Assembly:  A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase