Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

MedChemComm
2018.0

Abstract

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against <i>Trypanosoma brucei brucei</i>. Our study identified compounds <b>35</b>, <b>39</b>, <b>46</b>, <b>53</b> and <b>56</b> whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.

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