Permeability of Cyclic Peptide Macrocycles and Cyclotides and Their Potential as Therapeutics

Permeability of Cyclic Peptide Macrocycles and Cyclotides and Their Potential as Therapeutics Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties? Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability Interplay among Conformation, Intramolecular Hydrogen Bonds, and Chameleonicity in the Membrane Permeability and Cyclophilin A Binding of Macrocyclic Peptide Cyclosporin O Derivatives Design and synthesis of peptide-based macrocyclic cyclophilin inhibitors Passive Membrane Permeability of Macrocycles Can Be Controlled by Exocyclic Amide Bonds Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed