Insights into structural and physicochemical properties required for β-hematin inhibition of privileged triarylimidazoles

Insights into structural and physicochemical properties required for β-hematin inhibition of privileged triarylimidazoles Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites In vitro antimalarial activity, β-haematin inhibition and structure–activity relationships in a series of quinoline triazoles Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum Synthesis, antimalarial activity, structure–activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs Antimalarial acridines: Synthesis, in vitro activity against P. falciparum and interaction with hematin Incorporation of an intramolecular hydrogen bonding motif in the side chain of antimalarial benzimidazoles Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11