<jats:title>ABSTRACT</jats:title> <jats:p> The actinobacterium <jats:italic>Streptomyces wadayamensis</jats:italic> A23 is an endophyte of <jats:italic>Citrus reticulata</jats:italic> that produces the antimycin and mannopeptimycin antibiotics, among others. The strain has the capability to inhibit <jats:named-content content-type="genus-species">Xylella fastidiosa</jats:named-content> growth. The draft genome of <jats:italic>S. wadayamensis</jats:italic> A23 has ~7.0 Mb and 6,006 protein-coding sequences, with a 73.5% G+C content.