<jats:title>ABSTRACT</jats:title> <jats:p> Here, we report the draft genome sequence of <jats:italic>Streptomyces</jats:italic> sp. JV178, a strain originating from Connecticut (USA) garden soil. This strain produces the polycyclic tetramate macrolactam compounds clifednamides A and B. The draft genome contains 10.65 Mb, 9,045 predicted protein coding sequences, and several natural product biosynthetic loci.