<jats:title>ABSTRACT</jats:title> <jats:p> Here, we report the draft genome sequence of <jats:italic>Streptomyces</jats:italic> sp. TP-A0356, a producer of a potent antitumor antibiotic, yatakemycin, to evaluate potential for secondary metabolite production. The genome sequence data suggest the presence of at least nine gene clusters for polyketide synthases and nonribosomal peptide synthetases in this strain.