In order to explain the biogenesis of the ring-D epoxy-lactone in limonin, an attractive sequence of reactions and compounds has been assumed. It was suggested that the epoxy-lactone could be formed by a Baeyer-Villiger oxidative cleavage of a 14,15-epoxy-16-ketone formed from a Δ¹⁴-16 ketone in ring-D; such a system should originate from a compound of the apoeuphol type having a double bond at C-14 (methyl group at C-8). We report the isolation of three compounds with the appropriate systems in ring-D from the seed oil of Melia azadirachta L. (Nim oil), namely epoxyazadiradione (I; 1%), azadiradione (II; 0.8%), and azadirone (III; 0.0025%) along with the corresponding epoxy-lactones gedunin and 7-deacetylgedunin. The occurrence of all these compounds in the same plant supports the suggested biogenetic scheme.