Three new antifeeding meliacarpinins from chinese Melia Azedarach Linn

Tetrahedron
1995.0

Abstract

Melia azedarach L. are attracting considerable interest, particularly because of their insect antifeedant properties. The most potent constituent is azadirachtin, a limonoid which exerts strong physiological and phagorepellent activities. Several azadirachtin related compounds has been isolated and their structure-activity relationship has been also investigated well. M. azedarach is a native of Persia, India and China, but naturalized in a number of continents including Africa, Australia and Americas. Thus, the constituents of the tree have been studied in many regions to give degradated limonoids, azadirachtin and a related melianolone, trichilin-type 19/29 bridged acyl acetals, toosendanin and a related compound, salannin-type seco-limonoids, and so on. Recently, we isolated a new meliacarpinin 4 as an Insect antifeedant from Okinawan M. azedarach. In the continuous study of limonoid antifeedants from the Chinese plant collected at Cuangzhou, we have isolated three new meliacarpinins, named meliacarpinins B-D (l-3), along with 4, seven trichilins (5-11), four azedarachins (12-14), and nimbolinin B (16) and salannin (17). Their antifeeding activity was tested by a conventional leaf disk method against the Japanese voracious pest insects Spodoptera exigua Hirbner and S. midania (Boisduval). In this paper, we wish to report the structures of these meliacarpinins and the antifeedant activity of the isolated limonoids.

Knowledge Graph

Similar Paper