Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.

Knowledge Graph

Similar Paper

Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen
Bioorganic & Medicinal Chemistry Letters 2002.0
Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen
Bioorganic & Medicinal Chemistry Letters 2002.0
New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain
European Journal of Medicinal Chemistry 2012.0
Synthesis and structure–activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents
European Journal of Medicinal Chemistry 2008.0
Antimalarials. 11. Synthesis of 3- and 5-aminoquinolines as potential antimalarials
Journal of Medicinal Chemistry 1979.0
Bis-alkylamine quindolone derivatives as new antimalarial leads
Bioorganic & Medicinal Chemistry Letters 2010.0
New 4-Aminoquinoline Mannich Base Antimalarials. 1. Effect of an Alkyl Substituent in the 5‘-Position of the 4‘-Hydroxyanilino Side Chain
Journal of Medicinal Chemistry 1999.0
Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives
European Journal of Medicinal Chemistry 2016.0
Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4-aminoquinoline with potent antiplasmodial activity
Bioorganic & Medicinal Chemistry 2009.0
Antiparasitic hybrids of Cinchona alkaloids and bile acids
European Journal of Medicinal Chemistry 2013.0