Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum. (C) 2002 Elsevier Science Ltd. All rights reserved.

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