Fractionation of a cytotoxic extract of the stony coral Tubastrea faulkneri yielded a series of cytotoxic polyoxazole macrolides and several noncytotoxic indole derivatives. Two new macrolides, mycalolides D [1] and E [2], were isolated and identified, in addition to the known compound mycalolide C [3]. The macrolide structures were elucidated by detailed analysis of their spectroscopic data and by comparison with related compounds.