Some Unusual Proaporphine and Aporphine Alkaloids from Stephania venosa

Journal of Natural Products
1987.0

Abstract

New prmporphines found in Thai Stephania mosa include (+)-N-carboxamidostepharine 121, (-)-0-rnethylstepharinosine 131, and (-htepharinosine [5]. Alkaloid 2 is the first proaporphine incorporating a urea functionality, while 3 and 5 are the only proaporphines oxygenated at C-12. The plant also produces the new aporphines (-) sukhodianine-P-N-oxide 161, (-)-ushinsunine-P-N-oxide [T, and (- )-stephadiolamine-P-Noxide [SI. All three N-oxides are hydroxylated at C-7, but (-)-stephadiolarnine-p-N-oxide 181 is also hydroxylated at C-4. Thus, this is the first aporphine hydroxylated at both of these sites; 17 known isoquinoline alkaloids were also obtained.

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