TWO new alkaloids, tubacetine 131 and tubasenecine [4], were isolated from the aerial parrs of Haplophyllum tubercrrlatum (Rutaceae). Their identities were established from nmr data, including a study of the 2D INADEQUATE spectra of the monoterpene part of 3. In addition, the alkaloid 7-hydroxy-8-(3-methyI-2-butenyl)-4-methoxyfuro[2,3b]quinoline (51 has been identified in this source for the first time. Haplophyllum tuberculatum (Forssk. ) A. Juss. (Rutaceae) grows throughout Saudi Arabia, especially on fallow land and sandy soil. The flowering and fruiting branches of this plant are used by the public for a variety of ailments, including malaria, rheumatoid arthritis, and gynecological troubles (1). A number of constituents have been reported to occur in this plant; these include the lignans justicidin A and justicidin B (2), dyphyllin (2) and tuberculatin (2), and the quinoline alkaloids dihydroperfamine (3), 3-dimethylallyl-4-dimethylallyloxy-2-quinolone (4), evoxine (5), yfagarine (5), flindersine (4), folifine (6), haplofoline (6), and skimmianine (7). The amide tuberine 111 is the only tyramine alkaloid that has so far been reported (8) in this plant. This paper describes the isolation and structure elucidation of two related compounds, now named tubacetine [33 and tubasenecine 141. It also reports, for the first time, the presence of 7-hydroxy-8-(3-methyl-2-butenyl)-4-methoxyfuroE2,3b3quinoline 151 (10) in this source.