A novel alkaloid, clivonidine (4), was isolated from the total herb of C. miniata Regel cultivated in Egypt, and its structure was proved. Alkaloids lycorine (I), clivonine (2), and clivatine (3) were also isolated from this plant. The clivonidine alkaloid has an interesting structure from a biogenetic view-point. Clivia miniata Regel (Amaryllidaceae) is a handsome, ornamental perennial herb usually cultivated for its beautiful flowers. The plant is used to counteract snake-bite, to treat febrile conditions, and to facilitate delivery at childbirth (1). Leven, et af. (2-4) stated that the folkloric use of C. miniata Regel is due to its antiviral activity. They reported that alkaloid lycorine decreases the growth of polio in VERO cells through its inhibitory action on viral protein synthesis (2-4). Nine alkaloids were isolated from C. miniata Regel (5 - 15).