-A new alkaloid named nobilisine (5α-hydroxy-3α, 5a-epi-masan-7-one) {1} was isolated from Clivia nobilis cultivated in Egypt. Its structure was established from spectroscopic data utilizing mass spectral and two-dimensional 1H-nmr methods. Clivatine and lycorine were also isolated and identified as congeners of 1 in C. nobilis. © 1988, American Chemical Society. All rights reserved.