A study of the alkaloids of Clivia miniata

Chemistry of Natural Compounds
1975.0

Abstract

We studied the leaves and rhizomes of Clivia miniata Regel (family Amaryllidaceae) cultivated in Tashkent. The mixture of bases was extracted from the plant with chloroform. The combined alkaloids were treated with acetone, and lycorine was isolated. Analysis of the material collected in April (1972-1974) for its alkaloid content showed that the leaves contained 0.15-0.21% and the rhizomes 0.26% of combined alkaloids, in which lycorine amounted to 0.05-0.1%. After the isolation of lycorine, the combined alkaloids were chromatographed on a column of alumina (activity grade II) and eluted with benzene and benzene-ethyl acetate. From the eluates of benzene-ethyl acetate (1:2) we isolated hippeastrine, and from the (1:3) eluate a base (I) with mp 175-177°C (acetone), [α]D -191° (c 0.95; chloroform). A mixture of alkaloid (I) with caranine showed no depression of the melting point, and their IR and mass spectra were also identical. Thus, this is the first time that caranine has been isolated from C. miniata. This plant is also a source for the production of lycorine.

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