<jats:title>Abstract</jats:title><jats:p>The first phytochemical investigation on stems of <jats:italic>Mitrephora thorelii</jats:italic> led to the isolation of three new lignanamides, thoreliamides A–C (<jats:bold>1</jats:bold>–<jats:bold>3</jats:bold>), and a new sesquiterpenoid, thorelinin (<jats:bold>4</jats:bold>), together with ten known compounds. The structures of the new compounds were established on the basis of extensive spectroscopic analyses. Thoreliamide C is the first trimer derived from cinnamic acid amide units.