Esters of three new (hyponines D-F) and two known macrocyclic sesquiterpene pyridine alkaloid esters have been isolated from the root bark of Tripterygium hypoglaucum. The structures of the new alkaloids were elucidated as 7- (acetyloxy)-O-2-nicotinoyl-O-2-deacetyl-O-5-benzoyl-O-5-deacetyl-7-deoxo-evonine, 7- (nicotinoyloxy)-O-5-furanoyl-O-5-deacetyl-7-deoxo-evonine and 7- (acetyloxy)-O-2-furanoyl-O-2-deacetyl-7-deoxo-evonine by spectroscopic means. (C) 1999 Elsevier Science Ltd. All rights reserved.