Chondrofoline, a member of the rare group of 7,3'''-8',4' linked bis-benzyltetrahydroisoquinoline alkaloids, has been found in Uvaria ovata (Annonaceae); it has previously been found only in Triclisia patens Miers (Menispermaceae) [1]. Alkaloids of this type have previously been isolated only from Menispermaceae and Lauraceae [2] and their discovery in another, closely allied, Ranalean family yet again illustrates the potential value of alkaloids in the systematics of the Ranales. In a field screening of Mexican cacti for the presence of alkaloids, Echinocereus cinerascens (DC.) Rümpler and Pilosocereus chrysacanthus (Web.) Byl. et Rowl. were found to give positive tests with the Dragendorff reagent [1]. Plants were collected and the alkaloids extracted and studied. The present report describes the isolation and identification of the major phenethylamine alkaloids of these two cactus species.