Thirteen alkaloids were isolated from the stem-bark extract of Kopsia griffithii, of which three were new. These were the N(4)-oxides of akuammiline, 16-epi-deacetylakuammiline and 11,12-methylenedioxykopsinaline. Harmane, pleiocarpine and buchtienine showed antileishmanial activity. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.