Taxanes from the bark of Taxus brevifolia

Phytochemistry
1998.0

Abstract

Large-scale processing of the chloroform extract of the bark of Taxus brevifolia by reversed phase column chromatography on C-18 bonded silica using acetonitrile/water mixtures, gave a taxane-rich fraction which emerged just after the elution of paclitaxel. Re-chromatography of this fraction yielded 15 taxane constituents, many of which were obtained in crystalline form, and variously belonging to the 11(15→1) abeotaxane group, taxinine J group, brevifoliol group and those with an oxygenation pattern at the 14 position. Five of these were new and several others were isolated for the first time from this source.

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