<jats:title>Abstract</jats:title><jats:p>One new ceramide (=long‐chain base linked to a fatty acid <jats:italic>via</jats:italic> an amide bond), tanacetamide D (<jats:bold>1</jats:bold>), was isolated from <jats:italic>Tanacetum artemisioides.</jats:italic> Besides this, the two known constituents 5‐demethylnobiletin (<jats:bold>2</jats:bold>) and 5‐hydroxy‐3,6,7,8,3′,4′‐hexamethoxyflavone (<jats:bold>3</jats:bold>) were isolated for the first time from this species. The structure elucidation of the isolated compounds were based primarily on 2D‐NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple‐quantum coherence (HMQC), heteronuclear multiple‐bond correlation (HMBC), and nuclear <jats:italic>Overhauser</jats:italic> effect spectroscopy (NOESY) experiments.