Two new ceramides were isolated from the bulbs of Zephyranthes candida. Their structures were established as (2S,3S,4R,13E)-1,3,4-trihydroxy-2-[(2′R)-2′-hydroxytetracosanoylamino]-13-octadecene, named zephyranamide A (1) and (2S,3S,4R)-1,3,4-trihydroxy-2-octacosanoylaminohexadecene, named zephyranamide B (2). The structures of the new compounds were elucidated by spectral techniques including 1H NMR, 13C NMR, as well as HSQC, HMBC, DEPT, and COSY. To the best of our knowledge, this is the first isolation of ceramides from a plant in the genus Zephyranthes and even the family Amaryllidaceae.