Alkaloids ofBuxus sempervirens

Chemistry of Natural Compounds
1984.0

Abstract

The results of the analysis of the compounds isolated from Yeratrqzm dahuricum coincided with those of known alkaloids: (I) -- rubijervine; (II) -- veramarine; (III) -- veratroylzygadenine; (IV) -- jervine; (V) -- isorubijervine; (VI) -- verazine; and (VIII) -- veramine. This is the first time that the alkaloids (I)-(III) and (V)-(VII) have been isolated from Yeratrqzm dahuricum. The alkaloids of Buxus sempervirens L. cultivated in the environs of the town of Kobileti, Adzharsk ASSR, which had not previously been studied, were investigated. The amounts of alkaloids in various organs of this plant were determined by the chloroform method. The combined alkaloids of Buxus sempervirens, which consisted of a complex mixture of bases, were separated using McIlvaine's solutions at pH 8.0-2.2 and column chromatography on alumina and silica gel. Alkaloids (I) -- cyclobuxine-D, (II) -- cyclovirobuxine-D, (III) -- cyclobuxine-B, (IV) -- cycloprotobuxine-A, (V) -- cycloprotobuxine-D, and (VI) -- a base with mp 187-189°C were isolated. Alkaloids (I)-(V) were identified by mixed melting points, IR, NMR, and mass spectra of the bases and their derivatives. The IR and mass spectra of alkaloid (VI) showed it was a base of the type of 19-nor-B-homo-4,4'-trimethylpregnane-5, which differs from alkaloids previously isolated from the genus Buxus.

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