Polydiscamide A: a new bioactive depsipeptide from the marine sponge Discodermia sp

The Journal of Organic Chemistry
1992.0

Abstract

A depsipeptide, polydiscamide A (1), composed of 13 amino acids including a novel amino acid 3-methylisoleucine, was isolated from a Caribbean sponge, Discodermia sp. Its structure was elucidated by means of spectroscopic, chemical degradation, and derivatization techniques. Polydiscamide A inhibits the in vitro proliferation of the cultured human lung cancer A549 cell line.

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