Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta

The Journal of Organic Chemistry
1991.0

Abstract

A new macrocyclic lactam, discodermide (l), was isolated from a Caribbean marine sponge, Discodermia dissohta. Its structure was elucidated through a combination of spectroscopic techniques, in particular NMR spectroscopy. The carbon skeleton displayed by discodermide is new; discodermide is antifungal and cytotoxic.

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