<jats:title>ABSTRACT</jats:title> <jats:p> We report the draft genome sequence of <jats:italic>Streptomyces</jats:italic> sp. TP-A0874 isolated from compost. This strain produces catechoserine, a new catecholate-type inhibitor of tumor cell invasion. The genome harbors at least six gene clusters for polyketide and nonribosomal peptide biosyntheses. The biosynthetic gene cluster for catechoserines was identified by bioinformatic analysis.