The alkaloid composition of young shoots and leaves of Berberis heteropoda Schrenk has been studied. In addition to known alkaloids, two new ones have been isolated - N-methyldihydroberberine and 8-oxoberberrubine, the structures of which were established by chemical transformations and a study of spectral properties. Of known alkaloids, berbamunine, aromoline, glaucine, thalicmidine, isocorydine, and reticuline have been found in this plant for the first time. Pseudopalmitine and laudanosine have been found for the first time in plants of the genus Berberis. © 1993 Plenum Publishing Corporation.