A new N-benzylisoquinoline alkaloid - intebrine, with the composition C20H19NO7 - has been isolated from Berberis integerrima Bunge. The spatial structure of intebrine has been reliably determined by the x-ray structural method (diffractometer, CuKα radiation, 972 reflections, direct method, R=0.048). Its chemical behavior, spectral characteristics, and mass-spectrometric fragmentation under electrom impact have been studied. © 1993 Plenum Publishing Corporation.