In an investigation of the total alkaloids of Merendera robusta Bge, family Liliaceae from various growth sites as a promising raw material for obtaining colchamine and colchicine we have isolated for the first time merenderine and the new homoaporphine alkaloids merobustine and merobustinine, the structures of which have been established by chemical and spectral methods as 1,12-dihydroxy-2,10,11-trimethoxyhomoaporphine and 2,11-dihydroxy-1,10,12-trimethoxyhomoaporphine. © 1994 Plenum Publishing Corporation.