The new alkaloid robustamine has been isolated from the epigeal parts of Merendera robusta Bge., fam. Liliaceae, and its structure has been established by spectral methods and chemical transformations as 11-hydroxy-2, 12-dimethoxy-1,12-epoxyhexahydrohomoproaporphine, the suggested configuration being 6aS, 8aR, 11S, 12R. © 1996, Plenum Publishing Corporation. All rights reserved.