Compounds reacting with the Dragendorff reagent were detected in Maytenus buxifolia (A. Rich.) Griseb. (Celastraceae) [1]. Mayfoline has now been isolated from the aerial parts of the plant. Structure 1 with a characteristic hydroxylamine moiety is consistent with the spectroscopic and chemical properties of this alkaloid. Similar macrocyclic spermidine alkaloids occur in other Maytenus species and further Celastraceae [2, 3].