Alkaloids ofVeratrum oxysepalum

Chemistry of Natural Compounds
1982.0

Abstract

The composition of the alkaloids of Veratrum oxysepalum Turcz. has been studied incompletely. We investigated the ester alkaloids protoverine of the hypogeal part of the plant collected in the state of dormancy (August 14, 1977) in the environs of Magadan. By chromatography on a cellulose column impregnated with formamine, three alkaloids (I, II, III) were isolated and identified as dideacetylprotoveratrine A, deacetylprotoveratrine A, and protoveratrine A, respectively, which are first reported from this plant. Continuing the chemical study of Haplophyllum genus plants, we investigated H. ferganicum Vved. Stems collected in the flowering phase (May 23, 1980) in the Sadkak foothills, Fergana province, were extracted to obtain a crystalline alkaloid mixture (yield ~1%). Treatment and column chromatography yielded evoxine, 7-isopentenyloxyy-fagarine, evodine, haplopine, glycoperine, and other bases, with some identified by comparison with authentic samples from H. perforatum.

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