From the epigeal part of Haplophyllum perforatum growing on the northern slopes of the Babadag range we have isolated the known alkaloids evoxine, 7-isopentenyloxy-γ-fagarine. methylevoxine, evodine, skimmianine, glycoperine, haplamine, and haplopine and the new alkaloids haplofidine, triacetylglyoperidine and monoacetylglycoperidine. Diacetylglycoperine has been detected in the mixture of bases. It has been established that in the epigeal part, with the growth of the plant the amount of evoxine and its analogs decreases and the amounts of skimmianine, glycoperine, and haplofidine increase. The greatest number of alkaloids is found in the flowering period. It has been shown that haplofidine has the structure of 8-isopentenyloxy-4-methoxy-furanoquinoline, and triacetylglycoperine that of 4, 8-dimethoxy-7-α-L-triacetylrhamnosyloxy-furanoquinoline. © 1978 Plenum Publishing Corporation.