Benarthin: A new inhibitor of pyroglutamyl peptidase. I. Taxonomy, fermentation, isolation and biological activities.

The Journal of Antibiotics
1992.0

Abstract

We found benarthin, a new inhibitor of pyroglutamyl peptidase, in the fermentation broth of Streptomyces xanthophaeus MJ244-SF1. It was purified by column chromatography and centrifugal partition chromatography (CPC) and then was isolated as a colorless powder. The binding of benarthin was competitive with substrate and its inhibition constant (Ki) was 1.2 x 10(-6) M.

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