<jats:title>Abstract</jats:title><jats:p>Activity‐guided fractionation of the MeOH extract of the fruits of <jats:italic>Tetrapleura tetraptera</jats:italic> TAUB. (Mimosaceae) afforded <jats:bold>4</jats:bold> saponins <jats:bold>1</jats:bold>–<jats:bold>4</jats:bold>, which exhibited strong molluscicidal properties against the schistosomiasis‐transmitting snails <jats:italic>Biomphalaria glabrata.</jats:italic> Chemical, enzymatic, and spectral methods (DCI‐MS, <jats:sup>1</jats:sup>H‐NMR, <jats:sup>13</jats:sup>C‐NMR) showed that they were <jats:italic>N</jats:italic>‐acetylglycosides of oleanolic acid and of echinocystic acid. Apart from saponin <jats:bold>1</jats:bold> (aridanin), previously isolated from this plant, glycosides <jats:bold>2</jats:bold>–<jats:bold>4</jats:bold> are new naturally occurring compounds.