Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism.

Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism. Production of new anthracycline antibiotics 1-hydroxyoxaunomycin and 6-deoxyoxaunomycine by limited biosynthetic conversion using a daunorubicin-negative mutant. Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. I. Isolation of antibiotic-blocked mutants and their characterization. Production of new anthracycline antibiotics by microbial 4-O-methylation using a specific daunorubicin-negative mutant. Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5. New potent anthracyclines, barminomycins I and II. New potent anthracyclines, barminomycins I and II. A new anthracycline metabolite D788-1 (10-carboxy-13-deoxocarminomycin) in daunorubicin beer. Microbial conversion of .EPSILON.-pyrromycinone and .EPSILON.-isorhodomycinone to 1-hydroxy-13-dihydrodaunomycin and n-formyl-1-hydroxy-13-dihydrodaunomycin and their bioactivities. Microbial conversion of anthracyclinones to daunomycin by blocked mutants of Streptomyces coeruleorubidus.