Production of new anthracycline antibiotics 1-hydroxyoxaunomycin and 6-deoxyoxaunomycine by limited biosynthetic conversion using a daunorubicin-negative mutant.

Production of new anthracycline antibiotics 1-hydroxyoxaunomycin and 6-deoxyoxaunomycine by limited biosynthetic conversion using a daunorubicin-negative mutant. Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism. 13-Deoxycarminomycin, a New Biosynthetic Anthracycline 13-Deoxycarminomycin, a New Biosynthetic Anthracycline Production of new anthracycline antibiotics by microbial 4-O-methylation using a specific daunorubicin-negative mutant. Microbial conversion of .EPSILON.-pyrromycinone and .EPSILON.-isorhodomycinone to 1-hydroxy-13-dihydrodaunomycin and n-formyl-1-hydroxy-13-dihydrodaunomycin and their bioactivities. Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. I. Isolation of antibiotic-blocked mutants and their characterization. PHYSICAL AND CHEMICAL CHARACTERISTICS AND STRUCTURE OF CARMINOMYCIN, A NEW ANTITUMOR ANTIBIOTIC Microbial conversion of anthracyclinones to daunomycin by blocked mutants of Streptomyces coeruleorubidus. Microbial conversion of anthracyclinones to daunomycin by blocked mutants of Streptomyces coeruleorubidus.