A microbial metabolite inhibitor of CD28–CD80 interactions

Tetrahedron Letters
2002.0

Abstract

The organic extract of the fermentation broth of a Streptomycete microorganism was found to contain SCH 212394 (1), a condensed aromatic peptide. The structure was established by extensive NMR spectral data and derivatization. SCH 212394 (1), inhibited CD28–CD80 costimulation with an IC50 of 1.25 M.

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