4849F, a New Metabolite Produced by the Streptomyces sp. 4849 as an Inhibitor of IL-4 Receptor

The Journal of Antibiotics
2007.0

Abstract

A new compound named 4849F was isolated from the Streptomyces sp. 4849. The structure of 4849F was elucidated by spectroscopic analyses. The immobilized ligand-binding assay showed that 4849F can competitively inhibit the binding of IL-4 with IL-4 receptor in a dose dependent manner with an IC50 value of 6.7 microM.

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