Vepris heterophylla R. Letouzey (syn. Toddaliopsis heterophylla A. Engler, Teclea sudanica A. Chevalier), an African member of the Rutaceae used in folk medicine as a diuretic and an antipyretic, has been examined previously for some chemical constituents (1—5). In a continuation of our study, we investigated the alkaloids content of the leaves of V. heterophylla, which were collected in September 1992 from Mali (a voucher specimen N°. 88063 has been deposited at the Herbarium). The leaves were air-dried and extracted at room temperature with petroleum ether (60—80°C) and, after basification with ammonia solution, with CH₂Cl₂. The isolated material was purified on Amberlite XAD2 column using H₂O-MeOH mixtures of decreasing polarity. The H₂O-MeOH (1:4) fraction furnished evolatine (1) which was purified by chromatography on an alumina column with CHCl₃-MeOH (97:3) as eluent. The H₂O-MeOH (1:9) fraction and the MeOH fraction furnished kokusaginine (2) and tecleaverdoornine (3) purified by extensive gradient column chromatography (silica gel; CH₂Cl₂-MeOH mixtures) and preparative TLC (silica gel; CH₂Cl₂-MeOH 98:2). Evolatine (1) and kokusaginine (2) were recrystallized from methanol; tecleaverdoornine (3) was recrystallized in hexane-EtOH (50:50). The alkaloids were identified by direct comparison (UV, IR, ¹H-NMR, m.p.) with authentic samples and published data (6, 7). The occurrence of several related furoquinoline alkaloids in this species is typical of the Rutaceae (8). Hedyotis verticillata Lam. (Rubiaceae) is a small, harsh, sub-erect herb commonly found in open places throughout Malaysia. The leaves of the plant are used for making poultices and applied for headache and a decoction of the plant is drunk for the treatment of dysentery (1). Phytochemical studies previously done on the genus Hedyotis have led to the isolation of iridoids (2, 3), an alkaloid (4), triterpenes (5), and anthraquinones (6). No previous phytochemical investigation on H. verticillata has been reported. In this study we have isolated a flavonoid, 3,7-bis-(α-6-deoxymannopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-chromen-4-one or kaempferitrin and also observed that the compound exhibited toxicity in the brine shrimp test (7), LC50 21.9 µg/ml. Fresh leaves of H. verticillata were collected from the Sg. Besi district in Selangor; a voucher specimen no. 5684 was deposited at the Herbarium of Universiti Pertanian Malaysia. The methanolic extract (11 g) of the plant was partitioned between chloroform and water. The aqueous layer was then extracted in turn with ethyl acetate and butanol. The butanol extract (1.5 g) was subjected to column chromatography on silica gel (40 g) with CHCl₃ gradually enriched with methanol. Kaempferitrin was isolated from fractions six to eight (300 ml to 350 ml of eluant) and recrystallised from methanol as yellowish solid.