Isolation and identification of three new phenolic furoquinoline alkaloids from Teclea verdoorniana Exell & Mendonça (Rutaceae)

J. Chem. Soc., Perkin Trans. 1
2004.0

Abstract

Separation of the stem bark extracts of Teclea verdoorniana Exell & Mendonça (Rutaceae) yielded three new phenolic furoquinoline alkaloids, 8-hydroxy-5-(3-methylbut-2-enyl)-6,7-methylenedioxydictamnine (tecleaverdoornine) (1), 8-hydroxy-5-(3-hydroxy-3-methylbutyl)-6,7- methylenedioxydictamnine (tecleaverdine) (7), and 8-hydroxy-6,7-methylenedioxy- dictamnine (tecleine) (8), along with known alkaloids flindersiamine and kokusaginine. The pentacyclic triterpene lupeol was also isolated in large quantities. The application of ethanolic hydrochloric acid as a selective 4-O-demethylating reagent for dictamnine-type alkaloids is discussed.

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