Two pyrrolizidine alkaloids, heliscabine and retronecine, have been isolated from Heliotropium scabrum and their structures elucidated by physicochemical methods. Heliscabine, a new ester alkaloid is 1 alpha-angelyloxymethyl-8 alpha-pyrrolizidine-1 beta,7 beta-diol (9-angelyl helibractinecine).