The present study focuses on Neurada procumbens L. (Neuradaceae), a desert plant in Egypt with traditional medicinal uses. The whole plant was dried, ground, and successively extracted using solvents of increasing polarity, followed by column chromatography and spectral analysis for compound isolation and identification. Six flavonoids were obtained: taxifolin, taxifolin 3-O-α-rhamnopyranoside, vitexin, vitexin 200-O-α-rhamnopyranoside, orientin 200-O-α-rhamnopyranoside, and isoorientin 200-O-α-rhamnopyranoside, with five being isolated for the first time from this species. Chemosystematic analysis of these flavonoids, combined with morphological, anatomical, and molecular data, supports the placement of Neurada within the expanded Malvales, resolving the controversial systematic position of the genus.